Data from interim analysis support DB-020 as a potential therapy to protect patients against irreversible hearing loss associated with cisplatin chemotherapy
BOSTON, June 01, 2023 (GLOBE NEWSWIRE) -- Decibel Therapeutics (Nasdaq: DBTX), a clinical-stage biotechnology company dedicated to discovering and developing transformative treatments to restore and improve hearing and balance, today announced that it will present at the American Society of Clinical Oncology (ASCO) Annual Meeting, being held in Chicago, Illinois, June 2-6, 2023. The Company will present a poster summarizing data from the interim analysis of the Phase 1b clinical trial of DB-020, a novel, proprietary formulation of sodium thiosulfate (STS) designed to protect against hearing loss in cancer patients receiving cisplatin chemotherapy.
“Hearing loss and tinnitus are significant, often debilitating sequelae of cisplatin-induced ototoxicity, for which there are currently no approved therapies. Cisplatin remains an important chemotherapy for the treatment of multiple cancer types, and DB-020 is designed to protect the patient against cisplatin-induced ototoxicity,” said John Lee, Chief Development Officer of Decibel. “Data from the Phase 1b clinical trial demonstrate that treatment with DB-020 may result in a meaningful reduction in cisplatin-associated ototoxicity and support its continued development to potentially provide a therapy for an irreversible condition.”
The Phase 1b clinical trial was a randomized, blinded study in which patients were dosed with DB-020 in one ear and placebo in the contralateral ear in conjunction with their prescribed infusion of cisplatin chemotherapy. Additional information about the clinical trial can be found at clinicaltrials.gov.
Decibel’s ASCO presentation includes additional ototoxicity measures, which are consistent with the previously reported topline interim analysis data showing that 87% of patients who experienced cisplatin-induced ototoxicity in their placebo-treated ear were protected from ototoxicity in their DB-020-treated ear. Treatment with DB-020 prior to cisplatin administration had no apparent effect on systemic cisplatin levels. DB-020 was generally well tolerated, with no serious adverse effects and no tympanic perforations.
Poster presentation details:
Title: A Phase 1 clinical trial of DB-020 tympanic injections administered prior to high dose cisplatin chemotherapy to reduce ototoxicity
Session and track: Head and Neck Cancer – Advanced/Metastatic Disease
Abstract number: 6043
Poster board number: 35
Date and time: Monday, June 5th, 1:15 p.m. CDT
About Decibel Therapeutics
Decibel Therapeutics is a clinical-stage biotechnology company dedicated to discovering and developing transformative treatments to restore and improve hearing and balance, one of the largest areas of unmet need in medicine. Decibel has built a proprietary platform that integrates single-cell genomics and bioinformatic analyses, precision gene therapy technologies and expertise in inner ear biology. Decibel is leveraging its platform to advance gene therapies designed to selectively replace genes for the treatment of congenital, monogenic hearing loss and to regenerate inner ear hair cells for the treatment of acquired hearing and balance disorders. Decibel’s pipeline, including its lead gene therapy product candidate, DB-OTO, to treat congenital, monogenic hearing loss, is designed to deliver on our vision of creating a world of connection for people with hearing and balance disorders. For more information about Decibel Therapeutics, please visit www.decibeltx.com or follow us on Twitter.
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